The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537
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Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**

At 53, Josh Duhamel says he feels better than he did in his 30s.

Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age.

Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools.

The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance.

This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity.

You'll Learn:

  • Why Josh started testosterone therapy in his early 40s
  • How TRT changed his energy, strength, joints, and motivation
  • Why testosterone levels should be individualized
  • How injectable, oral, and topical testosterone differ
  • Why peptide sourcing matters
  • How GLP-1s can affect muscle and body composition
  • What Josh has tried for hair loss
  • Why brain performance became a major concern for him
  • Which nootropics come up for memory, focus, and mental stamina
  • Why becoming a father later in life changed how Josh thinks about longevity
  • How breathwork, psychedelics, and spirituality fit into the conversation

Thank you to our sponsors!

- Omni-Biotic | Discover your formula atOmnibioticLife.com. Take 20% off your first order with code ASPREY.

- MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.

- Timeline | Visittimeline.com/daveand get up to 20% off when you subscribe and save.

- Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go todrinkkenetik.com/DAVEand use code DAVE for a discount.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality

Resources:

• Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Timestamps:

00:00 – Trailer

01:15 – Intro

07:16 – Alcohol & Hangover Hacks

13:24 – Spirituality & Health

19:36 – Hormone Therapy for Women

24:45 – Inside Gatlan's Model

30:35 – Potty Training Secrets

38:39 – North Dakota & Fargo

43:57 – Hollywood's Beauty Secrets

50:19 – Acting Career & Longevity

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