The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290
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Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290

Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down withRick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures in psychedelic science. With nearly 40 years leading clinical research on MDMA, psilocybin, and trauma healing, Rick brings unmatched insight into how these compounds are transforming functional medicine, emotional resilience, and neuroplasticity.

They break down the regulatory battle over MDMA therapy, the clash between pharmaceutical profit and public benefit, and the urgent need to combine pharmacology with therapy for real results. You’ll also learn how psychedelics impact neurohacking, epigenetics, and the default mode network—and why the next frontier of self-transformation may be couples therapy with MDMA.

This episode offers critical knowledge for anyone serious aboutbiohacking, trauma release,mental performance, and accessing deeper states of healing. This podcast channel divesinto the intersections of psychedelics withfasting,ketosis,cold therapy, andself-quantification—and how altered states can unlock more energy, better relationships, and lasting change.

You’ll Learn:

• Why separating therapy from psychedelics is the most dangerous path forward

• How MAPS evolved into a public benefit pharma company—and what went wrong

• The real story behind the FDA’s rejection of MDMA therapy in 2024

• How MDMA affectsneuroplasticity,mitochondria, and trauma recovery

• Why group therapy and couples therapy are the future of psychedelic healing

• The dangers of overusing ketamine—and how it’s being exploited by profit-driven clinics

• What thePsychedelic Science 2025conference will reveal about the future of medicine, spirituality, andconsciousness hacking

• How psychedelics could reverseepigenetictrauma passed down through generations

• The role of default mode network suppression in spiritual experiences and trauma resolution

• Why the war on drugs was never about safety—and what a post-drug-war world might look like

Dave Asprey is a four-time New York Times bestselling author, founder ofBulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners,The Human Upgradeis the top podcast for people who want to take control of their biology, extend theirlongevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health,performance, neuroscience, supplements, nutrition,neurohacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

SPONSORS:

- Leela Quantum Tech |Head tohttps://leelaq.com/DAVEfor 10% off

- ARMRA |Go tohttps://tryarmra.com/and use the code DAVE to get 15% off your first order

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Psychedelic Science Conference 2025 Website – https://www.psychedelicscience.org/

• Rick’s Website: https://maps.org/

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

•00:00Trailer

•02:00Intro

•03:43Rise of Psychedelic Pharma

•05:00Therapy vs. Profit

•06:44Neurofeedback + Psychedelics

•08:28Origins of Drug Laws

•14:06MDMA Safety + Usage

•16:32Psychedelics in Therapy + Meditation

•25:18Psychedelic Hierarchy for New Users

•26:51Psychedelic Churches + Culture

•28:58Ayahuasca: Spiritual Insights

•30:24MDMA and Federal Policy

•31:09Inside the FDA Decision

•32:52Therapeutic Promise of Psychedelics

•34:43Psychedelics + Spirituality

•37:37Neuroscience of Psychedelics

•40:12Epigenetics + Generational Trauma

•43:50War on Drugs Revisited

•46:37Future of Legalization

•49:55MDMA for Couples

•51:29Group Therapy with Psychedelics

•52:26Psychedelic Science 2025 Preview

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