Decoding Stem Cell Rejuvenation Factors (Markus Gstöttner, CEO of Clock.bio)
Show: Translating Aging
Markus Gstöttner is the CEO of Clock.bio, a company devoted to extending and improving the quality of life by reversing the harmful effects of time in our cells. In this episode, Gstöttner shares how his company is working to extend healthspan by understanding and harnessing the natural rejuvenation capabilities of stem cells. The conversation explores Clock.bio's groundbreaking approach to identifying the genes and pathways involved in cellular rejuvenation, and their vision for translating these discoveries into therapies.
The Finer Details:
- How induced pluripotent stem cells (iPSCs) naturally resist and reverse aging
- Clock.bio's novel platform for forcing stem cells to age and studying their spontaneous rejuvenation
- The company's comprehensive genetic screen identifying over 150 rejuvenation-related genes, the Atlas of Rejuvenation Factors
- Strategies for validating these discoveries and developing therapeutic applications
- The path from discovery to clinical trials for extending human healthspan
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