Advancing Treatment Strategies in Advanced Leiomyosarcoma: Evidence for Oral Combination Therapy
In this episode of Better Edge, Oncologist Seth M. Pollack, MD, discusses the evolving treatment landscape for leiomyosarcoma and highlights clinical trial data recently published in The Lancet Oncology. Dr. Pollack was co-author on the study, which evaluated the combination of cabozantinib, a multitargeted tyrosine kinase inhibitor, with temozolomide in patients with refractory soft tissue sarcomas.
The conversation covers the biologic mechanisms underpinning this strategy, trial design and outcomes, and how the trial’s findings compare with existing systemic therapies. The discussion also emphasizes the value of referral to specialized sarcoma centers with multidisciplinary expertise and access to subtype specific clinical trials.
More From Current Show
In this episode of Better Edge, Geriatrician Eliana Gellar, DO, discusses how home-based care offers a window into...
Listen Now In this episode of Better Edge, Rheumatologist Irene Blanco, MD, moderates a multidisciplinary discussion with Nephrologist Yonatan Peleg,...
Listen Now As routine testosterone screening gains national attention, Nelson Bennett Jr., MD, discusses the importance of symptom-based evaluation, repeat...
Listen Now In this episode of Better Edge, Shan H. Siddiqi, MD, discusses how connectivity-based, image-guided neuro-navigation is refining transcranial...
Listen Now Nirmala Gonsalves, MD, discusses findings from the landmark DEGAS trial evaluating dupilumab in eosinophilic gastritis (EOG). She explores...
Listen Now In this episode of Better Edge, Eric Ruderman, MD, sits down with Anisha Dua, MD, and Brian Jaros,...
Listen Now In this episode of Better Edge, Melanie A. Stearns, MD, shares her approach to managing patients with functional...
Listen Now Related Episodes
Early recognition of progressive pulmonary fibrosis (PPF) is critical because further lung damage cannot be reversed. Teja Kulkarni,...
Listen Now 
How can I reduce smoke’s impact on my lungs at home? Aliaksandr Ramaniuk, DO, Physician in Cardiac Intensive...
Listen Now Worried about the next wildfire smoke event and what to do for your breathing? Aliaksandr Ramaniuk, DO, Physician...
Listen Now 
Dr. Adam Schertz walks through what asthma is, how it affects the lungs, common and surprising asthma triggers,...
Listen Now 
In this episode, we take a comprehensive, modern look at lung health—bridging chronic disease management, early cancer detection,...
Listen Now Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease that is often misdiagnosed, delaying treatment that can slow...
Listen Now 
Don’t let COPD flare-ups catch you off guard! In this episode, Dr. Nariv Shah explains what causes COPD...
Listen Now Early detection and advanced surgical care are changing the outlook for lung cancer. Discover how robotic technology is...
Listen Now 
