891 – The (Misleading) Truth About Akkermansia

Have you recently heard about Akkermansia and wondered what it's all about?  

We know it’s a commensal bacteria that resides in the human gut, thriving in the mucus layer, but its popularity in the wellness world has many asking: Are the benefits truly substantial?  

To answer this question let’s go over some common claims and what the research actually tells us.

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Timestamps

00:00  Intro 

02:06  What is Akkermansia?

04:29  “Only strain that lives and regulates the gut lining”

05:10  “Major part of the microbiome”

06:49  “Low levels are associated with poor gut health”

07:56  “Good for metabolism & gut health” 

10:30  Beware of “Positive Publication Bias”

12:14  Other probiotics that improve gut health

12:54  Increasing Akkermansia naturally

17:49  Key takeaways

18:54  Recommended protocol

Featured Studies 

• Akkermansia muciniphila: 18 years after its first discovery https://www.frontiersin.org/articles/10.3389/fgstr.2022.1024393/full

• Akkermansia muciniphila, a human intestinal mucin-degrading bacterium https://pubmed.ncbi.nlm.nih.gov/15388697/

• Role of Akkermansia in Human Diseases:  https://pubmed.ncbi.nlm.nih.gov/37111034/

• Akkermansia muciniphila improves glucose homeostasis https://pubmed.ncbi.nlm.nih.gov/33820962/

• Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans https://pubmed.ncbi.nlm.nih.gov/34223947/

• Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression https://pubmed.ncbi.nlm.nih.gov/36835309/

• Gut Bifidobacteria Populations in Human Health and Aging https://pubmed.ncbi.nlm.nih.gov/27594848/

• Akkermansia muciniphila in the Human GI Tract https://pubmed.ncbi.nlm.nih.gov/30041463/

• Intestinal Lactobacillus in health and disease, a driver or just along for the ride? https://pubmed.ncbi.nlm.nih.gov/28866243/

• Akkermansia lower in severe obesity https://pubmed.ncbi.nlm.nih.gov/31265324/

• Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/34085773/

• Akkermansia muciniphila in IBD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853388/

• Mucosa-Associated Microbiota in Patients with IBS https://pubmed.ncbi.nlm.nih.gov/33271532/

• Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease https://pubmed.ncbi.nlm.nih.gov/34884399/

• Gut microbiome of MS patients https://pubmed.ncbi.nlm.nih.gov/36113426/

• Probiotics fortify intestinal barrier function https://pubmed.ncbi.nlm.nih.gov/37168869/

• Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in IBS https://pubmed.ncbi.nlm.nih.gov/37686889/

• Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in IBD https://pubmed.ncbi.nlm.nih.gov/33555375/

• Effects of probiotics on functional constipation https://pubmed.ncbi.nlm.nih.gov/32005532/

• Probiotics for Preventing and Treating SIBO https://pubmed.ncbi.nlm.nih.gov/28267052/

• Probiotics as an effective therapeutic approach in alleviating depression symptoms https://pubmed.ncbi.nlm.nih.gov/35348020/

• Diets that differ in their FODMAP content alter the colonic luminal microenvironment https://pubmed.ncbi.nlm.nih.gov/25016597/

• Prebiotic Effect on Gut With Altered FODMAP Intake in Patients with Crohn's Disease https://pubmed.ncbi.nlm.nih.gov/27077959/

• Efficacy of a low FODMAP diet in IBS https://pubmed.ncbi.nlm.nih.gov/34376515/

• Lipoprotein and Endotoxemia Improvement in Metabolic Syndrome with Gut Microbiota Modification https://pubmed.ncbi.nlm.nih.gov/31451009/

• Regulation of gut microbiome by keto diet https://pubmed.ncbi.nlm.nih.gov/36313018/

• Islamic fasting leads to an increased Akkermansia https://pubmed.ncbi.nlm.nih.gov/31854308/

• Strategies to promote Akkermansia https://pubmed.ncbi.nlm.nih.gov/30416539/

• Adjuvant Probiotics Attenuate Glycemic Levels and Inflammatory Cytokines in Type 1 Diabetes Mellitus https://pubmed.ncbi.nlm.nih.gov/35299968/

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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g 

*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.