2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you canbend the rules of biologyto live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with herSeven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.

What You’ll Learn:

• TheSeven Tenets of Agingand how they’ll change your approach to health

• Why indulging in “bad” habits doesn’t have to sabotage your longevity

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk

• Thereal story behind NAD, circadian rhythms, and the tools for better sleep

• How to create a personalized health plan that’s sustainable, effective—and fun

Resources:

• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

•Kaufmann Protocol Website: https://kaufmannprotocol.com

• SandraKaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047

•Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

SPONSORS:

Leela Quantum | Head tohttps://leelaq.com/DAVEfor 10% off.

Timeline | Head tohttps://www.timeline.com/daveto get 10% off your first order.

Timestamps:

•00:00Trailer

•00:45Guest Introduction

•02:30Longevity Insights

•04:22Personal Stories

•08:00Pharmaceuticals

•12:26Diet and Lifestyle

•18:19Seven Tenets

•22:04Sleep and Circadian Rhythms

•26:41NAD and Supplements

•37:46Blood Sugar and AGEs

•47:09Microcirculation

•49:08NRS and Imports

•49:18Celebrex Medication

•50:03Celebrex Benefits

•50:41Alzheimer’s and Celebrex

•51:28Antioxidants

•54:26Stem Cells and Exosomes

•58:03Laser Skin Treatments

•01:07:34Hormones and Longevity

•01:20:03Lithium for Mood

•01:27:45Gender and Longevity

•01:32:39Final Thoughts

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